(TESTO IN ITALIANO SOTTO)
Atherosclerosis has features of an inflammatory disease: this underlines the importance of anti-inflammatory approaches to the prevention of atherosclerosis.
Atherosclerosis has features of an inflammatory disease: this underlines the importance of anti-inflammatory approaches to the prevention of atherosclerosis.
This reminds us the
importance of anti-inflammatory approaches to the diet too:
- reduction of insulin
release through a right management of carbohydrates intake
(expecially high-glycemic index ones)
- enough EPA and DHA
intake (long-chain fish-oil omega3 fatty acids)
The use of fish-oil
supplements purified through repeated molecular distillation is
strongly recommended (check the bottle before buying it).
COMMENTO IN ITALIANO:
(e sotto)
Source:
Circulation. 2002 Apr
16;105(15):1816-23.
Cyclooxygenase-2
promotes early atherosclerotic lesion formation in LDL
receptor-deficient mice.
Burleigh ME, Babaev VR,
Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD,
Fazio S, Linton MF.
Department of
Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn,
USA.
Abstract
BACKGROUND:
Atherosclerosis has
features of an inflammatory disease. Because cyclooxygenase (COX)-2
is expressed in atherosclerotic lesions and promotes inflammation, we
tested the hypotheses that selective COX-2 inhibition would reduce
early lesion formation in LDL receptor-deficient (LDLR-/-) mice and
that macrophage COX-2 expression contributes to atherogenesis in
LDLR-/- mice.
METHODS AND RESULTS:
Treatment of male LDLR-/-
mice fed the Western diet with rofecoxib or indomethacin for 6 weeks
resulted in significant reductions in atherosclerosis in the proximal
aorta (25% and 37%) and in the aorta en face (58% and 57%),
respectively. Rofecoxib treatment did not inhibit platelet
thromboxane production, a COX-1-mediated process, but it
significantly reduced the urinary prostacyclin metabolite
2,3-dinor-6-keto-PGF1alpha. Fetal liver cell transplantation was used
to generate LDLR-/- mice null for expression of the COX-2 gene by
macrophages. After 8 weeks on the Western diet, COX-2-/- -->
LDLR-/- mice developed significantly less (33% to 39%)
atherosclerosis than control COX-2+/+ --> LDLR-/- mice. In both
the inhibitor studies and the transplant studies, serum lipids did
not differ significantly between groups.
CONCLUSIONS:
The present studies
provide strong pharmacological and genetic evidence that COX-2
promotes early atherosclerotic lesion formation in LDLR-/- mice in
vivo. These results support the potential of anti-inflammatory
approaches to the prevention of atherosclerosis.
TESTO IN ITALIANO:
Danni dell'infiammazione –
2
L'aterosclerosi è una
malattia infiammatoria: questo sottolinea l'importanza degli approcci
anti-infiammatori nella prevenzione dell'aterosclerosi.
Questo ci ricorda anche
l'importanza dell'approccio anti-infiammatorio nella dieta:
- riduzione
dell'increzione di insulina tramite una corretta gestione
dell'apporto dei carboidrati (specialmente di quelli ad alto indice
glicemico)
- sufficiente apporto di
EPA e DHA (gli acidi grassi omega3 a lunga catena contenuti nell'olio
di pesce)
Si consiglia vivamente
l'uso di integratori di olio di pesce purificati mediante
distillazione molecolare ripetuta (controllare bene la confezione
prima di acquistare).
FONTE COMMENTATA:
Cyclooxygenase-2 promotes
early atherosclerotic lesion formation in LDL receptor-deficient mice
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