(TESTO IN ITALIANO SOTTO)
Pro-inflammatory cytokines and systemic inflammation initiate or worsen:
Pro-inflammatory cytokines and systemic inflammation initiate or worsen:
- Autoimmunity
- Alzheimer's disease
- atherosclerosis
The unregulated systemic
inflammation has a critical importance in common neurological and
cardiovascular disease that shortens the nominal longevity of humans.
So pay attention to foods
that stimulate the synthesis of mediators of inflammation:
high-glycemic index carbohydrates.
COMMENTO IN ITALIANO:
(e sotto)
Source:
Inflamm Res. 2000
Nov;49(11):561-70.
Unregulated inflammation
shortens human functional longevity.
Brod SA.
University of Texas Health
Science Center at Houston, Department of Neurology, 77225, USA.
Staley.a.brod@uth.tmc.edu
Abstract
Systemic inflammation,
represented in large part by the production of pro-inflammatory
cytokines, is the response of humans to the assault of the non-self
on the organism. Three distinct types of human ailments - namely
autoimmunity, presenile dementia (Alzheimer's disease), or
atherosclerosis - are initiated or worsened by systemic inflammation.
Autoimmunity is unregulated hyperimmunity to organ-specific proteins,
inducing rapid turnover of antigen-specific T cells of the acquired
immune system with ultimate exhaustion and loss of acquired immunity
IL-2 and IFN-gamma production and proliferative decline, conforming
to the limited capacity of clonal division (Hayflick phenonmenon). In
Alzheimer's disease (AD), the primary degenerative process of
amyloid-beta (AJ3) protein precedes a cascade of events that
ultimately leads to a local "brain inflammatory response".
Unregulated systemic immune processes are secondary but important as
a driving-force role in AD pathogenesis. Atherosclerosis, an
underlying cause of myocardial infarction, stroke, and other
cardiovascular diseases, consists of focal plaques characterized by
cholesterol deposition, fibrosis, and inflammation. The presence of
activated T lymphocytes and macrophages indicate a local immunologic
activation in the atherosclerotic plaque that may be secondary to
unregulated pro-inflammatory cytokines too. The premature
hyperimmunity of autoimmunity, the local "brain inflammatory
response" to A/3 protein in AD, and the immune response to fatty
changes in vessels in atherosclerosis all signal the critical
importance of unregulated systemic inflammation to common
neurological and cardiovascular disease that shortens the nominal
longevity of humans.
TESTO IN ITALIANO:
Danni dell'infiammazione –
1
Le citochine
pro-infiammatorie e l'infiammazione sistemica causano o peggiorano:
- Le malattie
autoimmunitarie
- Il morbo di Alzheimer
- L'aterosclerosi
L'infiammazione sistemica
sregolata ha un'importanza critica nelle comuni malattie neurologiche
e cardiovascolari che riducono la longevità degli uomini.
Attenzione, quindi, agli alimenti che stimolano la
sintesi dei mediatori pro-infiammatori: i carboidrati ad alto indice
glicemico.
FONTE COMMENTATA:
Unregulated inflammation
shortens human functional longevity.
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